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UID:biomedical-engineering-seminar-series-newark-2026@getjobtools.com
DTSTAMP:20261002T031104Z
DTSTART:20261106T153000Z
DTEND:20261106T163000Z
SUMMARY:Biomedical Engineering Seminar Series
DESCRIPTION:Megan L. McCain\, Ph.D. \n\n \n\nDepartment of Stem Cell Biol
 ogy and Regenerative Medicine\, Keck School of Medicine Alfred E. Mann De
 partment of Biomedical Engineering\, Viterbi School of Engineering Univer
 sity of Southern California (USC) \n\n \n\nSEMINAR: Engineering Microphys
 iological Systems to Decode Mechanobiological Drivers of Cardiac and Uter
 ine Disorders\n\nThe heart and the uterus are both muscular organs\, and 
 their physiological function depends on their ability to dynamically sens
 e and adapt to mechanical forces. In many diseases and disorders\, malada
 ptive responses to mechanical forces contribute to pathological remodelin
 g and tissue dysfunction. Microphysiological systems are powerful platfor
 ms for systematically investigating how mechanical forces regulate human 
 tissue physiology and pathophysiology. In this talk\, I will describe how
  we use microphysiological systems to identify the effects of mechanical 
 stretch on human cardiac and uterine muscle in disease-relevant contexts.
  We found that cardiomyocytes derived from patients with hypoplastic left
  heart syndrome\, a congenital heart defect\, exhibit pathological respon
 ses to cyclic stretch\, a stimulus that normally promotes cardiomyocyte m
 aturation. We also found that static stretch\, a defining feature of late
  stages of pregnancy\, modulates the oxytocin sensitivity of human uterin
 e smooth muscle cells\, with implications for understanding mechanisms of
  preterm labor. Together\, these studies demonstrate how microphysiologic
 al systems can reveal mechanobiological drivers of disease progression in
  the heart and uterus\, which can inspire new therapeutic strategies.. \n
 \nBIOSKETCH:\n\nMegan L. McCain\, Ph.D. is a Professor at the University 
 of Southern California (USC) in the Department of Stem Cell Biology and R
 egenerative Medicine and the Alfred E. Mann Department of Biomedical Engi
 neering. She also serves as Director of the Keck-Viterbi Center for Stem 
 Cell Engineering and Associate Chair of Biomedical Engineering. Her re
LOCATION:Ammon Pinizzotto Biopharmaceutical Innovation Center\, 140 AB\, 
 Newark\, DE\, United States
URL:https://events.udel.edu/event/biomedical-engineering-seminar-series-1
 340
STATUS:CONFIRMED
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